Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Doenja Hertog 1. Cases Series. Rui Henriques Martins Josias de Andrade Sobrinho AbrĂ£o Rapoport Marilene Paladino Rosa. Histopathologic features and management of .

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Peripheral soft tissue variantUnicystic variant. The histopathologic reclassification showed that follicular ameloblastoma 11 cases affected the body of the mandible in 6 cases, ameloblastooma ascendant ramus in 3 cases and the angle in 2 cases.


Ameloblastoma presenting as a multilocular radiolucency involving the left mandibular angle and ramus region. Abstract The aim of the present study is to examine all cases of intraosseous benign ameloblastomas treated between and in a single institution and to look for a possible correlation between the histopathological aspects and the demographical and clinical parameters, as well as the treatment outcome. Calcification in the fibrous stroma and occasional bone formation can also be seen.

While chemotherapyradiation therapycurettage and liquid nitrogen have been effective in some cases of ameloblastoma, surgical resection or enucleation remains the most definitive treatment for this condition. Palisading basal cells and stellate reticulum.

Histopathologic features and management of ameloblastoma: study of 20 cases

In contrast to typical ameloblastoma, this variant frequents the maxilla and the anterior region of the jaws.

Another excluded patient was diagnosed with a metastasis of a previously treated cutaneous basal cell carcinoma, extending into the cortical bone of the mandible and mimicking an ameloblastoma. Usually asymptomatic and can be found incidentally on routine dental examinations Can also present as a painless swelling or expansion of jaw Pain and paresthesia are uncommon Slow growing, rarely metastasizes to lungs or CNS Metastases associated with tumor of long duration, multiple surgical procedures, radiation therapy Associated with nevoid basal cell carcinoma Gorlin syndrome Fam Cancer ; They are slow growing and cause little or no bone erosion.


This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pathologically significant pericoronal lesions in adults: Other effects include tooth mobility, displacement of teeth, resorption of roots, paraesthesia if the inferior alveolar canal is involved, failure of eruption of teeth and very rarely the ameloblastoma can ulcerate through the mucosa.

The anatomopathological classification of the ameloblastoma is not yet routine, but we are convinced that dealing with the differences in histologic patterns is relevant in establishing surgical procedures, from the simplest biopsies and bone scraping to the most invasive acts.

The results were statistically analysed using the Kappa, Student T-test, Chi square test and the Anova test. Am Assoc Dent Sch Trans.

According to Li, Fabian and Goodman, 10 surgery is the only treatment for ameloblastoma, due to its resistance to irradiation therapy. There is no gender ameloblasttoma. The histopathological typing of the biopsies and surgical specimens has been performed by one experienced oral pathologist. Author information Article notes Copyright and License information Disclaimer.

Photomicrographs depicting acanthomatous variant of ameloblastoma depicting follicles exhibiting extensive squamous metaplasia and keratin formation.

However, only few cases have been reported associated with known genetic syndrome i. Within the mandible, the molar angle ramus area is involved three times more commonly than are premolar and anterior regions combined. Page views in Figure 1 – Photomicrograph of follicular ameloblastoma hematoxylin eosin x Wed Nov 28 This page was last edited on 23 May ameolblastoma, at Figure 5C and D: Maxillary ameloblastoma and extraosseous ameloblastoma occur in a slightly older age group while unicystic ameloblastoma Avg Use of hitopathology in the differential diagnosis of unicystic ameloblastomas.


J Oral Maxillo-fac Surg.

Please help improve this article by adding citations to reliable sources. This is very much like surgical treatment of cancer.

This article has been cited by other articles in PMC. The data of a total number of 44 patients were retrieved from the records. The follicular pattern consist of islands of epithelial cells with a central mass of polyhedral cells or loosely arranged angular cells resembling stellate reticulum, surrounded by ameloblasyoma organized single layer of cuboidal or tall columnar cells with nuclei placed at the opposite pole ameloblastomz basement membrane resembling pre-ameloblasts.

Anastassov et al 11 have reported that radiotherapy alone or associated with chemotherapy is only indicated for patients of advanced age.

Adenomatoid odontogenic tumor Keratocystic odontogenic tumour. Epub Oct Recurrent ameloblastoma in an autogenous bone graft after 28 amelooblastoma The single case of a primary malignant ameloblastoma has been excluded from the present study.

The widening of our knowledge will allow us to find solutions yistopathology fight ameloblastoam the overall harmful effects of such tumors. Figure 3B and C: The background is usually eosinophilic and shows scattered spindle cells and inflammatory cells. Diagnostic criteria for unicystic ameloblastoma: Int J Oral Maxillofac Surg.

Ameloblastoma is tentatively diagnosed through radiographic examination and must be confirmed by histological examination e. No statistically significant differences were found between the histopathological sub types of ameloblastomas and the demographical and clinical parameters, nor between the histopathological sub types and treatment outcome.