Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Please review our privacy policy. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. In addition, we observed that a serum uric acid level above 5. Closed symbols represent data collected after 4—6 days of HFrD. These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.

It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose fructise HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Nutr Metab Lond ; 9: Am J Physiol Renal Physiol ; Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal mechanism of the metabolic syndrome.

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The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake. hyperuricema

As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance. These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia. No other potential conflicts of interest relevant to this article were reported. This mechanism indyced substantially enhance the risk of gout in people who consume high amounts of sugar.

Urinary UA excretion rate. Published online Aug After the infusion of fructose, 0. National Center for Biotechnology InformationU.

The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0. Author information Copyright and License information Disclaimer.

Acknowledgments This study was supported hyperuriccemia grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. Because the fructoae effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.

This effect appears to be specific for fructose.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were The serum Pi level decreased 2. The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose infusion. The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.

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In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose. F—F [ PubMed ]. Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1. Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition.

Open in a separate window. This article has been cited by other articles in PMC. Although the cumulative fructose load was large 1.